Shortened High-dose Palliative Radiotherapy for Lung Cancer (Ship-Rt)

Study Updates

Ship-Rt is open to recruitment at University Hospital Coventry,  Royal Shrewsbury Hospital, and University Hospital Birmingham, and will be opening at 1 more site in 2025. 

For Enquiries:

Tel: 02476 966581
Email: shiprt@uhcw.nhs.uk



Participating Sites

Study Information

Chief Investigator & Team

Chief Investigator: Dr Raj Shrimali

PI at University Hospitals of North Midlands NHS TrustDr Apurna Jegannathen

PI at University Hospitals Birmingham NHS Foundation TrustDr Qamar Ghafoor

PI at Shrewsbury and Telford Hospital NHS TrustDr Anirban Chatterjee

Lead Coordinator: Mani Thind 

Sponsor

University Hospitals Coventry & Warwickshire NHS Trust 

Funder

UHCW Charity 

Coventry Hospitals Charity

Aim

To investigate the safety and efficacy of reducing the number of RT fractions and RT duration, compared to the current standard of care (36Gy in 12 fractions over 16 days), by using shortened hypofractionated accelerated palliative radiotherapy (30Gy in 6 alternate-day fractions), aided by contemporary RT planning, verification, and delivery techniques.

Study Design

Multi-centre, Prospective, Single arm, Phase II study (including safety and feasibility), with a Simon two-stage optimal design

Speciality

Lung Cancer

Summary

Patients diagnosed with lung cancer that has spread beyond one lung are said to have stage IV lung cancer. Treatment is aimed at controlling the symptoms of cancer and making patients live longer Typically, doses of 36 Gray (Gy) is delivered in 12 daily treatments (excluding weekends) of radiotherapy are used and take about 16 days. The SHiP-Rt study will explore the possibility of using fewer radiation treatments to deliver similar radiotherapy doses, thereby shortening the overall duration, without any additional side effects. Side effects are temporary but include discomfort in swallowing food, cough, and breathlessness. It is not known if receiving 30Gy in 6 treatments would be more or less effective than 36Gy in 12 treatments which is the current standard of care.

We aim to investigate whether delivering the SHiP-Rt treatment regime doses of 30 Gy in 6 treatments given every other day (excluding weekends) is a safe and feasible alternative, using modern radiotherapy techniques.

Planned Start Date

April 2024

Planned Duration

36 months

Target Sample Size

37

Results

Results will be published and available here once the study has completed and all data analysed.