Patients & healthcare professionals views on tourniquet use in surgery (PHP-VTS)

Study Updates

The PHP-VTS study was opened at University Hospital Coventry and The Royal London Hospital as of December 2023. The study closed to recruitment in December 2024 and the results will now be analysed.  

For Enquiries:

Tel: 02476 967476

Email: AffixtStudyOffice@uhcw.nhs.uk

Participating Sites

Study Information

Chief Investigator & Team

Chief Investigator: Professor Julie Bruce

PI at Royal London Hospital: Mr Lucky Jeyaseelan

PhD Student: Muhamed Farhan-Alanie

Lead Coordinator: Cristiana Huhulea

Sponsor

University of Warwick

Funder

National Institute of Health and Care Research (NIHR) - Doctoral Fellowship

Aim

This mixed methods study aims to inform the design of a future trial investigating tourniquet use in ankle fracture fixation surgery through involvement of key stakeholders including patients, operating department practitioners, surgeons, and anesthetists.

Study Design

Multicentre (two centres) mixed-methods study involving:

1. Focus groups with patients

2. Interviews with operating department practitioners

3. Nominal Group Technique consensus meeting with Trauma & Orthopaedic Surgeons and Anaesthetists

Speciality

Trauma & Orthopaedics

Summary

Tourniquets are commonly used during ankle fracture fixation surgery. This is a device which is applied around the thigh and stops blood flowing through the leg during the operation. Some surgeons believe it helps reduce intraoperative blood loss and improves their field of view, reducing operative time. However, tourniquets have been associated with various adverse effects such as increased pain, and risk of blood clot formation inside the deep veins of the leg (which can occasionally break off and travel to the lungs). Tourniquets also reduce the amount of oxygen being delivered to the soft tissues which might increase the risk of wound healing complications. Considering the clinical uncertainty regarding tourniquet use, a well-designed, multicentre trial addressing the flaws and limitations of previous studies is required to inform clinical practice. This study aims to inform the design of a future trial investigating tourniquet use in ankle fracture fixation surgery through involvement of key stakeholders (patients, surgeons, and anaesthetists). Participants will be recruited from the University Hospital Coventry & Warwickshire and Royal London Hospital. It consists of two parts:

A) Focus group meetings will take place with patients who have undergone ankle fracture fixation surgery. We will
explore patients’ views on recovering from ankle fracture fixation surgery, what outcomes matter most to them and their
knowledge about tourniquet use. The focus group sessions will be recorded, transcribed verbatim and anonymised.

B) A virtual nominal group technique consensus meeting will take place with Orthopaedic Trauma surgeons and
anaesthetists. The results will help refine three key design considerations: participant eligibility criteria, techniques for
blinding patients and the surgical team, as well as refining parameters of the intervention and control arms.

C) Interviews with operating department practitioners - this will help in developing the method to blind surgeons and patients from tourniquet use during the perioperative period. These practitioners commonly apply tourniquets on patients' limbs and communicate their status to the surgeons throughout the operation.
This three-staged approach will help ensure the results of the future trial are informative to clinical practice from the perspectives of stakeholders.

Planned Start Date

August 2023

Planned Duration

26 months

Target Sample Size

35

Results

Results will be published once the study has completed and all data analysed.