Physiotherapy and Optimised Enteral Nutrition In the post-acute phase of critical illness (PHOENIX): A randomised controlled feasibility study

Study Updates

The PHOENIX Study was open to recruitment at University Hospitals Coventry and John Radcliffe Hospital. It closed to recruitment in January 2025 having met 100% of the target, and has finished follow-ups as of April 2025.

Our study was recently featured on BBC News! Click here to read the article.

For Enquiries:

Tel: 02476 966197
Email: phoenixstudyoffice@uhcw.nhs.uk

Participating Sites


Study Information

Chief Investigator & Team

Chief Investigator: Professor David McWilliams

PI at John Radcliffe Hospital, Oxford: Dr Owen Gustafson

Lead Coordinator: Violet Matthews

Sponsor

University Hospitals Coventry and Warwickshire NHS Trust

Funder

National Institute for Health and Care Research (NIHR) RfPB

Aim

To assess the feasibility and acceptability of individualised physiotherapy and optimised nutrition, delivered on the ward post ICU to increase days alive and out of hospital, as well as the proposed methodology to optimise design and delivery for a definitive evaluation trial.

Study Design

A mixed-methods, multicentre, randomised controlled feasibility study.

Speciality

Critical Care

Summary

Up to two thirds of patients discharged from ICU have ongoing significant physical, psychological and cognitive morbidity (‘post intensive care syndrome’). As a result, survivors of critical illness are often left with complex rehabilitation needs, adversely impacting return to pre-illness quality of life and function. In the longer-term, a third of working age patients still need help with basic activities (e.g., going to the toilet, getting dressed), 50% have been readmitted to hospital, and less than half have returned to work one year after leaving ICU.

The development and widespread implementation of structured, individualised interventions to support patients on ICU step down has the potential to improve overall recovery and quality of life. The James Lind Alliance Intensive Care Priority Setting Partnership highlighted the need for research on supporting recovery after intensive care as a key research priority. A national service evaluation of twenty-five centres in the UK highlighted that at step down from ICU 98% patient of patients required ongoing physiotherapy and 70% were at risk of malnutrition.

Over three-quarters of UK ICUs provide follow-up teams intended to optimise the care of patients in hospital following an ICU stay. The purpose of follow-up teams is to aid the transition to the ward, support the ward teams with ongoing care such as tracheostomy weaning, improve lines of communication between services, and identify clinical deterioration. These teams were often developed with little evidence to support their practice and the ICU Getting it Right First-Time report and a recent systematic review demonstrated wide variation in provision.

This study is focused on muscle loss resulting in reduced mobility and malnutrition. It is a mixed-methods, two-centre, randomised controlled feasibility study to establish the viability of conducting a larger multicentre RCT to test the effects of the combined physiotherapy and nutritional intervention on days alive and out of hospital in 30 days.

Planned Start Date

April 2024

Planned Duration

18 months

Target Sample Size

60 

Results

Results will be published once the study has completed and all data analysed.